Accession Number : ADA332648

Title :   Effect of Hormone Replacement Therapies and Dietary Phytoestrogens on the Mammary Gland of Macaques

Descriptive Note : Annual rept 1 Jul 96-30 Jun 97

Corporate Author : BOWMAN GRAY SCHOOL OF MEDICINE WINSTON-SALEM NC

Personal Author(s) : Cline, J. M.

PDF Url : ADA332648

Report Date : JUL 1997

Pagination or Media Count : 64

Abstract : The purpose of this study has been to use histomorphometric and immunohistochemical techniques to study the incidence and characteristics of mammary gland hyperplasia, dysplasia and other possible indicators of breast cancer risk, in cynomolgus macaques given long-term hormonal treatments. Treatments evaluated to date include conjugated estrogens (CEE), medroxyprogesterone acetate (MPA), the combination of CEE and MPA, tamoxifen, estradiol (E2), 17alpha-dihydroequilenin (DHEN), soybean phytoestrogens (SBE), and SBE + E2. Pathologic evaluation, histomorphometric evaluations, and staining for estrogen receptor, progesterone receptor, and the proliferation marker Ki-67 MIB were done.

Descriptors :   *HORMONES, *MAMMARY GLANDS, *ESTROGENS, *BREAST CANCER, PATHOLOGY, SOYBEANS, IMMUNOCHEMISTRY, HISTOCHEMISTRY, PROGESTERONE, DYSPLASIA.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE