Accession Number : ADA332667

Title :   Preclinical Studies on the Potential Use of Swainsonine with High-Dose Chemotherapy in Humans: Chemoprotective and Hemarestorative Properties.

Descriptive Note : Annual rept. 1 Jul 96-30 Jun 97

Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s) : White, Sandra

PDF Url : ADA332667

Report Date : JUL 1997

Pagination or Media Count : 21

Abstract : The overall goal of these pre-clinical studies is to optimize the therapeutic potential of the novel agent, swainsonine, for utilization in the management of myelosuppression associated with high-dose chemotherapy, a method of treatment currently being used for human metastatic and high-risk primary breast cancer. Our initial studies have focused on determining the optimal dose, schedule and timing of swainsonine treatment to protect against the toxicity associated with multiple cycles of chemotherapy, administered similar to that used in humans. Our studies have clearly demonstrated, for the first time, that survival in mice receiving methotrexate and swainsonine is 7-fold greater than that in mice receiving methotrexate only. Thus swainsonine is able to significantly protect mice from the chemotoxicity associated with up to 3 cycles of methotrexate. The relationship between this increase in survival and swainsonine's known effect on hematopoietic cells is currently under study in non-tumor bearing and tumor-bearing mice.

Descriptors :   *TOXICITY, *CLINICAL MEDICINE, *HEMATOPOIETIC SYSTEM, *CHEMOTHERAPY, OPTIMIZATION, HIGH RATE, HUMANS, NEOPLASMS, SURVIVAL(GENERAL), CYCLES, DOSAGE, THERAPY, MICE, CELLS(BIOLOGY), DOSE RATE, METHOTREXATE.

Subject Categories : Biochemistry
      Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE