Accession Number : ADA332827

Title :   Effects of Serotonergic Compounds on Stress-Induced Behavior in Rats.

Descriptive Note : Final rept. 1 Jul 94-30 Jun 97,

Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER SHREVEPORT

Personal Author(s) : Dunn, Adrian J. ; Swiergiel, Artur H.

PDF Url : ADA332827

Report Date : 31 AUG 1997

Pagination or Media Count : 6

Abstract : Because our earlier experiments with fenfluramine and serotonin antagonists did not provide encouraging results, we decided to study effects of endotoxin (lipopolysaccharide, LPS) and interleukin- 1, (IL-1) which are known to reduce food intake, and which we have shown also alter cerebral serotonergic and noradrenergic metabolism. Thus it is possible that there is a relationship between the activation of these cerebral neurotransmitter systems and the hypophagia. Specifically, it can be hypothesized that LPS- and IL-1-induced hypophagia are related to the increased noradrenergic and serotonergic activity. This hypothesis has been tested using a variety of neurotransmitter receptor antagonists for their ability to antagonize LPS- or IL-1-induced hypophagia in mice. Several behavioral experiments were completed.

Descriptors :   *STRESS(PHYSIOLOGY), *SEROTONIN, RATS, NOREPINEPHRINE, BEHAVIOR, NEUROTRANSMITTERS, ENDOTOXINS, LIPOPOLYSACCHARIDES, ANXIETY.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE