Accession Number : ADA332847

Title :   Observations on Bilateral Mastectomy: Resource Evaluation.

Descriptive Note : Annual rept. 15 Jul 96-14 Jul 97

Corporate Author : PITTSBURGH UNIV PA

Personal Author(s) : McCarty, Kenneth

PDF Url : ADA332847

Report Date : AUG 1997

Pagination or Media Count : 12

Abstract : This observational study involves the evaluation of a cohort of patients who had undergone a modified radical mastectomy for primary breast cancer and then underwent a contralateral subcutaneous mastectomy at the time of reconstruction. The study extends clinical follow-up to a minimum of 10 years, methodically reviews the histology of the primary mastectomy and contralateral mastectomy materials and compares the cohort to several control groups treated 'conventionally' without contralateral subcutaneous mastectomy. Initial evaluation of the cohort demonstrates a remarkable disease free survival compared to similar patients with similar tumors not exposed to contralateral subcutaneous mastectomy. The survival advantage is observed to be maximal the closer the second procedure was performed to the primary mastectomy, mitigating against the result being due to time to procedure selection bias. The study of the contralateral specimens for frequency and pattern of epithelial hyperplasia associated with contralateral cancer and the cataloguing of findings is being carried out to establish a resource for in-situ molecular studies on such unique material associated with whole gland evaluation.

Descriptors :   *CLINICAL MEDICINE, *BREAST CANCER, *MASTECTOMY, TEST AND EVALUATION, GROUP DYNAMICS, MOLECULES, DISEASES, RESOURCES, SURVIVAL(PERSONNEL), BIAS, SELECTION, HISTOLOGY, GLANDS.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE