Accession Number : ADA332856

Title :   Assessment of the Potential Drug Etiology of Breast Cancer: Analyses of Data from a Case-Control Drug Surveillance Study

Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97

Corporate Author : BOSTON UNIV MA

Personal Author(s) : Rosenberg, Lynn

PDF Url : ADA332856

Report Date : SEP 1997

Pagination or Media Count : 15

Abstract : The purpose of the present study is to assess the potential drug etiology of breast cancer through analyses of data from our hospital-based Case-Control Surveillance Study. We carried out computer 'screens' of the data to detect unsuspected associations: the use of each drug or drug class among women with breast cancer was compared to that among women admitted for other conditions. Odds ratios were significantly elevated or reduced for several drugs; these relationships will be assessed in detailed analyses. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated in several studies with a reduced risk of large bowel cancer. We assessed NSAID use in relation to breast cancer risk in comparisons of 6558 cases of breast cancer to 3296 cancer and 2925 noncancer controls. In the analysis using noncancer controls, the odds ratio was compatible with a small reduction in the risk of breast cancer among regular users of NSMDs. However, the reduction was attributable to one study center that contributed less than 10% of the data. With cancer controls there was no reduction. The results, including analyses of the duration and timing of use, do not support an inverse association between NSAID use and the risk of breast cancer.

Descriptors :   *ETIOLOGY, *BREAST CANCER, CASE STUDIES, DRUGS, EPIDEMIOLOGY, PHARMACOLOGY, ANTIINFLAMMATORY AGENTS.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE