Accession Number : ADA332867

Title :   The Identification of Estrogen Responsive Genes in the Hypothalamic-Pituitary Axis

Descriptive Note : Annual rept 1 Jul 96- 30 Jun 97

Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s) : Connor, Caroline E. ; McDonald, Donald P.

PDF Url : ADA332867

Report Date : JUL 1997

Pagination or Media Count : 12

Abstract : Estrogen mediates its biological responses through a specific interaction with the estrogen receptor (ER), an intracellular transcription factor which can bind specific DNA sequences and regulate gene expression. This process, however, is highly dependent on the cell and promoter context of the DNA-bound receptor, and our laboratory has demonstrated that the nature of the ligand also plays an important role. The identification of novel tissue-specific genes can therefore aid in the development of selective ligands for ER. Our laboratory is interested in defining estrogen-responsive genes in the hypothalamic-pituitary axis.

Descriptors :   *GENES, *ESTROGENS, INTERACTIONS, PITUITARY GLAND, DEOXYRIBONUCLEIC ACIDS, LIGANDS, RESPONSE(BIOLOGY), CELLS(BIOLOGY), PITUITARY HORMONES, HYPOTHALAMUS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE