Accession Number : ADA332876

Title :   Steroid Receptors Functions In Vivo and Breast Cancer

Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97

Corporate Author : VIRGINIA UNIV CHARLOTTESVILLE

Personal Author(s) : Jeng, Meei-Huey

PDF Url : ADA332876

Report Date : AUG 1997

Pagination or Media Count : 8

Abstract : Women with estrogen receptor positive breast tumors respond to adjuvant hormonal therapy with an enhancement of disease free survival and overall survival. A substantial fraction of tumors are dependent upon estrogen for growth, and antiestrogen has been shown to be effective for the treatment of breast cancer. The precise mechanism of estrogen and anti-estrogen action in breast tumors still remain unclear. We postulated that estrogen and anti-estrogen act by activating the function of the endogenous estrogen receptor. Using rat mammary gland as the model, we examined the function of ER in response to estrogen and antiestrogen. Our data suggested that estrogen and anti-estrogen are able to activate and regulate the function of estrogen receptor in a cell context dependent fashion. We conclude that estrogen and anti-estrogen may exert their effects on the growth of target tissues, at least in part, by increasing the functional activity of the endogenous estrogen receptor. Abstracts for the research done in this funding period were submitted to the Annual Endocrine Meeting in June, 1997 and Era of Hope DOD BCRP Meeting in October, 1997 for presentation.

Descriptors :   *ESTROGENS, *BREAST CANCER, TISSUES(BIOLOGY), GROWTH(GENERAL), NEOPLASMS, SURVIVAL(GENERAL), THERAPY, WOMEN, MAMMARY GLANDS.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE