Accession Number : ADA332973
Title : Basic Research Effort Toward Development of a Vaccine Against Human Brucellosis; Identification of Protective Brucella Antigens and Their Expression in Vaccinia Virus to Prevent Disease in Animals and Humans
Descriptive Note : Annual rept 1 May 96-30 Apr 97
Corporate Author : VIRGINIA POLYTECHNIC INST BLACKSBURG
Personal Author(s) : Schurig, Gerhardt G.
PDF Url : ADA332973
Report Date : SEP 1997
Pagination or Media Count : 22
Abstract : This project intends to identify Brucella antigens which are likely to stimulate Th1 responses (with production of lNF-gamma) with lymphocytes from vaccinated mice and therefore, are likely to have a role in the induction of protective immunity against brucellosis. Once such antigens have been identified, the genes encoding those antigens will be isolated, sequenced and their products will be characterized. Using these genes, recombinant vaccinia viruses will be constructed.
Descriptors : *VACCINES, *BRUCELLOSIS, HUMANS, BACTERIA, CODING, GENES, ANIMALS, MICE, IMMUNITY, ANTIGENS, IMMUNIZATION, LYMPHOCYTES, BRUCELLA, VACCINIA VIRUS.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE