Accession Number : ADA333265

Title :   Receptors, Afferent Signaling and Central Integration in Compensated and Uncompensated Hemorrhagic Shock.

Descriptive Note : Annual progress rept. 1 Jan-31 Dec 97,

Corporate Author : IOWA UNIV IOWA CITY

Personal Author(s) : Johnson, Alan K.

PDF Url : ADA333265

Report Date : DEC 1997

Pagination or Media Count : 11

Abstract : To examine the mechanisms by which melanopeptides and hypertonic saline activate pressor mechanisms during hemorrhagic shock. Approach: Hemorrhagic shock is induced in rats by the controlled withdrawal of specific blood volumes, graded by body weight. Mean arterial pressure (MAP) and heart rate (HR) serve as indices of cardiovascular flinction, and ultimately as indicators of hemorrhage-induced shock. In this model of hemorrhagic shock, the melanopeptide, y-MSH, is administered peripherally or centrally, post-hemorrhage, to determine the therapeutic potential of the compound in treating hemorrhagic shock. The ability of y-MSH and hypertonic saline to increase survivability under the condition of hemorrhagic shock is being evaluated.

Descriptors :   *HEMORRHAGIC SHOCK, VOLUME, SURVIVABILITY, MODELS, INTEGRATION, SIGNALS, THERAPY, MEAN, COMPENSATION, HEART RATE, BODY WEIGHT, BLOOD PRESSURE.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE