Accession Number : ADA333279

Title :   Custom Tailoring Therapy for Breast Cancer Using erbB-2

Descriptive Note : Final rept. 15 Dec 92-14 Dec 94

Corporate Author : GEORGETOWN UNIV WASHINGTON DC

Personal Author(s) : Paik, Soonmyoung

PDF Url : ADA333279

Report Date : 05 JUN 1995

Pagination or Media Count : 16

Abstract : In order to examine the role of erbB-2 as a therapeutic response variable in breast cancer, 937 cases from NSABP B-l4 and 207 cases from NSABP B-11 were examined using immunohistochemical assay. Both studies failed to demonstrate the value of erbB-2 in predicting response to specific treatment regimens used in the studies (tamoxifen or adriamycin). In order to clone additional therapeutic response variables that may predict response to tamoxifen, we have used gene trap approach. A novel estrogen suppressed gene was partially cloned. in addition, we were able to confirm estrogen regulation of bcl-2 gene, which could be a potential predictor of tamoxifen response.

Descriptors :   *BREAST CANCER, THERAPY, GENES, CELLS(BIOLOGY), MAMMARY GLANDS, ESTROGENS.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE