Accession Number : ADA333384

Title :   Suppression of Lymphocyte Signal Transduction by Oxygen Intermediates

Descriptive Note : Annual rept 30 Sep 96-29 Sep 97

Corporate Author : NEW YORK UNIV MEDICAL CENTER TUXEDO NY

Personal Author(s) : Flescher, Eliezer

PDF Url : ADA333384

Report Date : OCT 1997

Pagination or Media Count : 53

Abstract : Effects of different types of oxidative stress (OS) on cellular anti-oxidant mechanisms were compared. Human blood lymphocytes were subjected to: a. Acute exposure to H2O2; b. Chronic exposure to H2O2; c. Ionizing radiation. Enhanced catalase activity was detected in human peripheral blood T lymphocytes exposed to oxidative stress. Glutathione peroxidase activity and reduced glutathione, vitamin C and vitamin E levels, were not modulated by oxidative stress. Only exposure to hydrogen peroxide at 20 micrometer did not enhance catalase activity in T lymphocytes.

Descriptors :   *STRESS(PHYSIOLOGY), *OXIDATION, *LYMPHOCYTES, HUMANS, TOXICITY, OXYGEN, TRANSDUCERS, T LYMPHOCYTES, ANTIOXIDANTS, PEROXIDASES, GROWTH(PHYSIOLOGY), GLUTATHIONE, HYDROGEN PEROXIDE, CATALASE, VITAMIN E.

Subject Categories : Biochemistry
      Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE