Accession Number : ADA334020

Title :   Structure and Function of the Ankyrin Repeats in the SWi4/SWi6 Transcription Complex of Budding Yeast.

Descriptive Note : Annual rept. 8 Jul 96-7 Jul 97,

Corporate Author : FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA

Personal Author(s) : Breeden, Linda

PDF Url : ADA334020

Report Date : SEP 1997

Pagination or Media Count : 17

Abstract : A large and diverse set of proteins have been identified as containing ankyrin repeats, including several proteins in which the ankyrin repeat motifs may play a role in tumor development. These include Bcl-3, int-3, TAN-i, and pi6. The BCL-3 gene encodes a member of the I kappa B family of proteins and rearrangements involving the ankyrin repeat region BCL-3 have been identified in B-cell chronic lymphocytic leukemias (14). Int-3, a mouse proto-oncogene, is a common insertion site for the Mouse Mammary Tumor Virus (MMTV). Activation of the int-3 ankyrin repeat sequences by MMTV produces poorly differentiated adenocarcinoma of the mammary and salivary glands in mice (10). TAN-i, the human Notch homologue, was first described as a breakpoint region oft (7,9) gene rearrangements found in T-cell acute lymphoblastic leukemias. This rearrangement places the gene encoding the beta T-cell receptor adjacent to the ankyrin repeat motifs of TAN-i (5). p16 is the protein product of theMTSJ (multiple tumor suppressor-i) gene. It is composed of only a series of four ankyrin repeats and is one member of the cyclin dependent kinase inhibitor family of proteins. p16 can compete with cyclin D and displace the cyclin subunit from its kinase binding site, thereby inhibiting (ji to S progression through the cell cycle. Mutations in p16 have been noted in a variety of human tumors and tumor cell lines, in addition, mutations have been found in the germline of families predisposed to melanoma (9).

Descriptors :   *MAMMARY GLANDS, *BREAST CANCER, HUMANS, PROTEINS, NEOPLASMS, GENES, T LYMPHOCYTES, CELLS(BIOLOGY), LEUKEMIA.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE