Accession Number : ADA334028

Title :   Structure and Inhibition of the neu/erbB-2 Receptor.

Descriptive Note : Annual rept. 1 Sep 96-31 Aug 97,

Corporate Author : YALE UNIV NEW HAVEN CT

Personal Author(s) : Smith, Steven

PDF Url : ADA334028

Report Date : SEP 1997

Pagination or Media Count : 36

Abstract : Cancer results from a breakdown in the normal mechanisms which control the growth and division of cells. For many cells, the signals for initiating cell division are hormone molecules that bind to receptors on the surface of the cell. The signal is transmitted through the cell membrane by one or more receptor molecules. Receptors in an "active" state (with hormones bound) initiate a cascade of events which starts the replication machinery. Uncontrolled cell transformation often results when the receptors on the cell surface are "turned on" even in the absence of the signaling hormone. The research undertaken here has been to study the structure of one critical membrane receptor, the neu or erbB-2 receptor, whose activation has been associated with a large number of breast and ovarian cancers.

Descriptors :   *CELLS(BIOLOGY), *BREAST CANCER, HORMONES, MEMBRANES(BIOLOGY), MOLECULES, CELLS, SURFACES, SIGNALS, CELL DIVISION, SENSE ORGANS, TRANSFORMATIONS, MAMMARY GLANDS, EXPLOSIVES INITIATORS, OVARIES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE