Accession Number : ADA334061

Title :   The Effects of Melatonin on Menstrual Characteristics, Prolactin, and Premenstrual Syndrome-Like Symptoms during a Simulated Eastward Deployment.

Descriptive Note : Final rept.,

Corporate Author : ARMY AEROMEDICAL RESEARCH LAB FORT RUCKER AL

Personal Author(s) : Comperatore, Carlos A.

PDF Url : ADA334061

Report Date : OCT 1997

Pagination or Media Count : 66

Abstract : Melatonin (N-acetyl-5-methoxytryptamine),a natural hormone which has been shown to resynchronize circadian rhythms and induce sleep in humans (Arendt et al., 1987; Dawson and Encel, 1993; Reiter, 1991; Wurtman, 1986), is currently being marketed widely as a dietary supplement to alleviate desynchronosis (desynchronization of physiological and behavioral rhythms) and assist in obtaining quality sleep. Desynchronosis often results from rapid shifts in work schedules from day to night, or from shifts in the light- dark cycle due to time zone crossing. Symptoms resulting from desynchronosis include fatigue, sleepiness, lethargy, insomnia, gastrointestinal tract disorders, and poor mental performance (for review see Comperatore and Krueger, 1990). Melatonin therapy has been demonstrated to be effective in preventing sleep loss and in maintaining alertness following travel across multiple time zones (Arendt and Broadway, 1987; Comperatore et al., 1996; Petrie et al., 1989). Thus, melatonin can be a potentially effective chronobiotic and ameliorate desynchronosis during travel.

Descriptors :   *CIRCADIAN RHYTHMS, *THERAPY, *SLEEP DEPRIVATION, *MELATONIN, HORMONES, HUMANS, TIME SERIES ANALYSIS, SIGNS AND SYMPTOMS, CYCLES, NIGHT, MENTAL ABILITY, DAYLIGHT, GASTROINTESTINAL SYSTEM, MENSTRUATION, INSOMNIA, PROLACTIN.

Subject Categories : Anatomy and Physiology
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE