Accession Number : ADA334433

Title :   Mutations in ATM, Radiation Exposure and Breast Cancer Risk Among Black and White Women.

Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97,

Corporate Author : WASHINGTON UNIV SEATTLE

Personal Author(s) : Schubert, Elizabeth

PDF Url : ADA334433

Report Date : AUG 1997

Pagination or Media Count : 15

Abstract : Predisposition to breast cancer is inherited as a genetic trait in some families. Thus far, a few highly penetrant genes responsible for inherited breast cancer have been identified. An important and unresolved question of breast cancer etiology is whether there are other genes which have a more moderate effect on breast cancer risk, possibly triggering disease only in the presence of specific environmental exposures, and possibly involving more women than do other, highly penetrant mutations. It has been suggested that mutations in the Ataxia- Telangiectasia gene (ATM) and radiation exposure could be involved with breast cancer in this manner. In order to address this question, we are screening a series of breast cancer patients for mutations in the ATM gene. This series of patients was selected for either radiation exposure, radiation sensitivity, inheritance of a single ATM allele through multiple affected members of a family, or having a child with Ataxia-Telangiectasia. This study will detect potential mutations in the ATM gene which confer breast cancer risk, particularly mutations which may lead to radiation sensitivity.

Descriptors :   *EXPOSURE(GENERAL), *RADIATION ABSORPTION, *BREAST CANCER, HUMANS, MINORITIES, DISEASES, MUTATIONS, PENETRATION, ETIOLOGY, GENES, PATIENTS, WOMEN, GENETIC MAPPING, CAUCASIANS, ATAXIA.

Subject Categories : Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE