Accession Number : ADA334527

Title :   The Roles of Nitric Oxide, cGMO, and cGMP-Dependent Protein Kinase in Generation and Modulation of Circadian Rhythms by the Suprachiasmatic Nucleus

Descriptive Note : Final rept

Corporate Author : AIR FORCE RESEARCH LAB BOLLING AFB DC

Personal Author(s) : Weber, Edward T.

PDF Url : ADA334527

Report Date : 1995

Pagination or Media Count : 111

Abstract : Research in this thesis addresses these two functions of the mammalian circadian pacemaker at a neurochemical level, examining the regulation of guanosine cyclic 3',5'- monophosphate (cGMP) and cGMP-dependent protein kinase (PKG) as components of the circadian pacemaker, and also investigating the roles of nitric oxide, cGMP, and PKG in transmitting environmental light cycle information to the pacemaker, possibly through regulation of the transcriptional factor, cAMP-response element binding protein (CREB).

Descriptors :   *CIRCADIAN RHYTHMS, MAMMALS, PROTEINS, THESES, NEUROCHEMISTRY, PHYSIOLOGY, NITROGEN OXIDES, PHOSPHATES, BIOPHYSICS, ADENOSINE, GUANOSINE, PHOSPHORUS TRANSFERASES, NUCLEOSIDES, PACEMAKERS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE