Accession Number : ADA334527
Title : The Roles of Nitric Oxide, cGMO, and cGMP-Dependent Protein Kinase in Generation and Modulation of Circadian Rhythms by the Suprachiasmatic Nucleus
Descriptive Note : Final rept
Corporate Author : AIR FORCE RESEARCH LAB BOLLING AFB DC
Personal Author(s) : Weber, Edward T.
PDF Url : ADA334527
Report Date : 1995
Pagination or Media Count : 111
Abstract : Research in this thesis addresses these two functions of the mammalian circadian pacemaker at a neurochemical level, examining the regulation of guanosine cyclic 3',5'- monophosphate (cGMP) and cGMP-dependent protein kinase (PKG) as components of the circadian pacemaker, and also investigating the roles of nitric oxide, cGMP, and PKG in transmitting environmental light cycle information to the pacemaker, possibly through regulation of the transcriptional factor, cAMP-response element binding protein (CREB).
Descriptors : *CIRCADIAN RHYTHMS, MAMMALS, PROTEINS, THESES, NEUROCHEMISTRY, PHYSIOLOGY, NITROGEN OXIDES, PHOSPHATES, BIOPHYSICS, ADENOSINE, GUANOSINE, PHOSPHORUS TRANSFERASES, NUCLEOSIDES, PACEMAKERS.
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE