Accession Number : ADA334721

Title :   Interaction of Light and Clock Regulation in Neurospora

Descriptive Note : Final rept 1 Jun 94-30 Sep ,97

Corporate Author : DARTMOUTH MEDICAL SCHOOL HANOVER NH DEPT OF PHARMACOLOGY AND TOXICOLOGY

Personal Author(s) : Loros, Jennifer J.

PDF Url : ADA334721

Report Date : SEP 1997

Pagination or Media Count : 11

Abstract : Interest is focused on understanding the molecular mechanisms involved in how eukaryotic cells and organisms keep time on a daily basis and how visible light entrains the clock mechanism at the molecular level (Seminars in the Neurosciences, 7: 3-13, 1995). In the model organism, Neurospora crassa, ambient light has been shown to act either independently of, or coordinately through the circadian pacemaker. Significant advances in our understanding of how light effects a single component of the clock and thereby results in entrainment of clock phase has been made by examinaion of light effects on the frequency locus transcript, a known component of the I clock (Cell 81, 1003 - 1012, 1995). Analysis of clock-output genes find them involved in a diverse set of cell functions, photo-inducibility to be clock independent. Promoter resection analysis shows sequences necessary and sufficient for clock-independent light regulation.

Descriptors :   *CIRCADIAN RHYTHMS, *NEUROSPORA, INTERACTIONS, FUNGI, GENES, NEUROLOGY, CELLS(BIOLOGY), RIBONUCLEIC ACIDS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE