Accession Number : ADA334730

Title :   Steroid Hydroxylase Activities as Noninvasive Biomarkers of Toxicant Exposure and Effect

Descriptive Note : Final rept 1 Jun 94- 31 Oct 97

Corporate Author : NORTH CAROLINA STATE UNIV AT RALEIGH CUTANEOUS PHARMACOLOGY AND TOXICOLOGY CENTER

Personal Author(s) : Leblanc, Gerald A.

PDF Url : ADA334730

Report Date : OCT 1997

Pagination or Media Count : 45

Abstract : Biomarkers of chemical exposure and effect have substantial utility in chemical hazard and risk assessments. The overall goal of this research project was to test the hypothesis that changes in the metabolic elimination of the steroid hormone testosterone could serve as a non-invasive biomarker of toxicant exposure and effect in a variety of sentinel species and humans.

Descriptors :   *EXPOSURE(PHYSIOLOGY), *STEROIDS, HORMONES, HUMANS, CHEMICALS, TOXICITY, ENZYMES, METABOLISM, MARKERS, ENDOCRINOLOGY, TESTOSTERONE.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE