Accession Number : ADA334733

Title :   Relationships of Blood and Brain Halocarbon Solvent Concentrations to Neurobehavioral Toxicity

Descriptive Note : Final rept

Corporate Author : AIR FORCE RESEARCH LAB BOLLING AFB DC

Personal Author(s) : Warren, David A.

PDF Url : ADA334733

Report Date : 1995

Pagination or Media Count : 127

Abstract : Time-courses of blood and brain concentrations and neurobehavioral toxicity were determined for two halocarbon solvents in two rodent species. Based on these data, quantitative relationships, or the lack thereof, have been reported between the degree of neurobehavioral toxicity and internal measures of dose. In the case of orally- administered perchloroethylene (PCE), relationships between blood and brain concentrations and operant performance were not discernable, due in part to an acute adaptation of rats to PCE's response suppressing effect. For inhaled 1,1,1- trichloroethane (TRI), blood and brain concentrations were strongly correlated with the rate of operant responding in rats.

Descriptors :   *TOXICITY, *BEHAVIOR, *NEUROBIOLOGY, BRAIN, RATS, THESES, CARBON, DOSAGE, SOLVENTS, PHARMACOKINETICS, HALOGENATED HYDROCARBONS, CONCENTRATION(CHEMISTRY), BLOOD, CHLORINATED HYDROCARBONS, TRICHLOROETHANES, EXTRAPOLATION.

Subject Categories : Toxicology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE