Accession Number : ADA334733
Title : Relationships of Blood and Brain Halocarbon Solvent Concentrations to Neurobehavioral Toxicity
Descriptive Note : Final rept
Corporate Author : AIR FORCE RESEARCH LAB BOLLING AFB DC
Personal Author(s) : Warren, David A.
PDF Url : ADA334733
Report Date : 1995
Pagination or Media Count : 127
Abstract : Time-courses of blood and brain concentrations and neurobehavioral toxicity were determined for two halocarbon solvents in two rodent species. Based on these data, quantitative relationships, or the lack thereof, have been reported between the degree of neurobehavioral toxicity and internal measures of dose. In the case of orally- administered perchloroethylene (PCE), relationships between blood and brain concentrations and operant performance were not discernable, due in part to an acute adaptation of rats to PCE's response suppressing effect. For inhaled 1,1,1- trichloroethane (TRI), blood and brain concentrations were strongly correlated with the rate of operant responding in rats.
Descriptors : *TOXICITY, *BEHAVIOR, *NEUROBIOLOGY, BRAIN, RATS, THESES, CARBON, DOSAGE, SOLVENTS, PHARMACOKINETICS, HALOGENATED HYDROCARBONS, CONCENTRATION(CHEMISTRY), BLOOD, CHLORINATED HYDROCARBONS, TRICHLOROETHANES, EXTRAPOLATION.
Subject Categories : Toxicology
Distribution Statement : APPROVED FOR PUBLIC RELEASE