Accession Number : ADA334893
Title : Function of Cell Cycle Control Proteins in Breast Cancer.
Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97,
Corporate Author : HARVARD MEDICAL SCHOOL BOSTON MA
Personal Author(s) : Hinds, Phillip W.
PDF Url : ADA334893
Report Date : SEP 1997
Pagination or Media Count : 67
Abstract : Loss of the retinoblastoma tumor suppressor protein (pRb) can contribute to breast tumor formation. However, many breast tumors retain expression of normal pRb, indicating that other genetic events may interfere with the function of this growth regulatory protein. Overexpression of cyclin Dl is such an event, since high levels of this protein may lead to constitutive inactivation of pRb through phosphorylation.
Descriptors : *PROTEINS, *CELLS(BIOLOGY), *BREAST CANCER, NEOPLASMS, CYCLES, RETINA, GENETICS, TRANSFORMATIONS, MAMMARY GLANDS, SUPPRESSORS, PHOSPHORYLATION.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE