Accession Number : ADA334912

Title :   Development of PEA3 as a Potential Gene Therapy Agent for Breast Cancer

Descriptive Note : Annual rept 1 Sep 96-31 Aug 97

Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s) : Xiangming, Xing

PDF Url : ADA334912

Report Date : SEP 1997

Pagination or Media Count : 28

Abstract : 13. ABSTRACT (Maximum 200 The HER-2/neu gene is frequently amplified and /or its protein product, p185, is frequently overexpressed in a number of human cancers. Overexpression of p185 correlates with poor prognosis and low survival rates in breast and ovarian cancer patients. Downregulation of HER-2/neu gene is a way to reverse the transformation phenotype induced by HER-2/neu. In this project, the effects of PEA3, a member of ets oncogene family of transcriptional regulatory factors, on HER-2/neu expression were investigated to learn whether PEA3 plays a role in HER-2/neu induced transformation and could be developed to a gene therapeutic agent. This progress report includes our recent data which demonstrating that, PEA3 is indeed a trans-repressor of HER-2/neu promoter in HER-2/neu overexpressing human cancer cells.

Descriptors :   *GENES, *BREAST CANCER, HUMANS, PROTEINS, NEOPLASMS, THERAPY, CELLS(BIOLOGY), SUPPRESSION, TRANSFORMATIONS, GROWTH(PHYSIOLOGY), OVARIES.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE