Accession Number : ADA334931

Title :   TGFa-myc Interactions in Mammary Tumorigenesis.

Descriptive Note : Annual rept. 1 Sep 96-31 Aug 97,

Corporate Author : GEORGETOWN UNIV WASHINGTON DC

Personal Author(s) : Dickson, Robert B.

PDF Url : ADA334931

Report Date : SEP 1997

Pagination or Media Count : 68

Abstract : This grant continues to study the nature of the synergistic interaction of the growth factor TGF alpha and the nuclear protooncogene product c-myc for bitransgenic mouse mammary tumorigenesis. We found evidence of a mu!tifactoral interaction of the two genes, involving cooperative stimulation of proliferation, anchorage independent colony formation, and suppression of cell death (apoptosis). In addition, we observed that the TGF alpha-related growth factor amphiregulin was likely to have tumor promoting effects similar to"TGF alpha in breast' cancer.

Descriptors :   *GENES, *GROWTH(PHYSIOLOGY), *BREAST CANCER, INTERACTIONS, PROTEINS, NEOPLASMS, DEOXYRIBONUCLEIC ACIDS, MICE, CELLS(BIOLOGY), SUPPRESSION, SYNERGISM, MAMMARY GLANDS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE