Accession Number : ADA335004

Title :   Mutations in ATM, Radiation Exposure and Breast Cancer Risk Among Black and White Women

Descriptive Note : Annual rept 26 Aug 96-25 Aug 97

Corporate Author : WASHINGTON UNIV SEATTLE

Personal Author(s) : King, Mary C.

PDF Url : ADA335004

Report Date : SEP 1997

Pagination or Media Count : 14

Abstract : Predisposition to breast cancer is inherited as a genetic trait in some families. Thus far, a few highly penetrant genes responsible for inherited breast cancer have been identified. An important and unresolved question of breast cancer etiology is whether there are other genes which have a more moderate effect on breast cancer risk, possibly involving more women than do other inherited mutations. It has been suggested that mutations in the Ataxia-Telangiectasia gene (ATM) and radiation exposure could be involved with breast cancer in this manner. In order to address this question, we are screening a series of breast cancer patients for mutations in the ATM gene. This series of patients was selected for radiation exposure, radiation sensitivity, inheritance of a single ATM allele through multiple affected relatives, and/or having a child with AT. This study will detect potential mutations in the ATM gene which may confer breast cancer risk, particularly any which may lead to radiation sensitivity.

Descriptors :   *RADIATION, *MUTATIONS, *EXPOSURE(PHYSIOLOGY), *BREAST CANCER, RISK, ETIOLOGY, GENES, WOMEN, X RAY ABSORPTION ANALYSIS, CAUCASIANS, AFRICAN AMERICANS.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE