Accession Number : ADA335059

Title :   Cell-Matrix Interactions in Breast Cancer Cells

Descriptive Note : Final rept 15 Aug 94-14 Aug 97

Corporate Author : NORTHWESTERN UNIV EVANSTON IL

Personal Author(s) : Jones, Jonathon C.

PDF Url : ADA335059

Report Date : SEP 1997

Pagination or Media Count : 214

Abstract : In the normal breast, epithelial cells adhere to the connective tissue via junctions called hemidesmosomes. Using in vitro models, we have shown that hemidesmosomes play an important role in determining correct tissue architecture in the developing breast. They do so by the coordinated function of a matrix component (laminin-5) and its integrin receptors. Laminin-5 appears to direct hemidesmosome assembly as well as breast epithelial duct morphogenesis. To do so this matrix element requires precise

Descriptors :   *INTERACTIONS, *CELLS(BIOLOGY), *BREAST CANCER, EPITHELIUM, TISSUES(BIOLOGY), ADHESION, IN VITRO ANALYSIS, ELECTRON MICROSCOPY, MAMMARY GLANDS, CONNECTIVE TISSUE, IMMUNOCHEMISTRY.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE