Accession Number : ADA335059
Title : Cell-Matrix Interactions in Breast Cancer Cells
Descriptive Note : Final rept 15 Aug 94-14 Aug 97
Corporate Author : NORTHWESTERN UNIV EVANSTON IL
Personal Author(s) : Jones, Jonathon C.
PDF Url : ADA335059
Report Date : SEP 1997
Pagination or Media Count : 214
Abstract : In the normal breast, epithelial cells adhere to the connective tissue via junctions called hemidesmosomes. Using in vitro models, we have shown that hemidesmosomes play an important role in determining correct tissue architecture in the developing breast. They do so by the coordinated function of a matrix component (laminin-5) and its integrin receptors. Laminin-5 appears to direct hemidesmosome assembly as well as breast epithelial duct morphogenesis. To do so this matrix element requires precise
Descriptors : *INTERACTIONS, *CELLS(BIOLOGY), *BREAST CANCER, EPITHELIUM, TISSUES(BIOLOGY), ADHESION, IN VITRO ANALYSIS, ELECTRON MICROSCOPY, MAMMARY GLANDS, CONNECTIVE TISSUE, IMMUNOCHEMISTRY.
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE