Accession Number : ADA335064
Title : Gene Therapy Mediated Breast Cancer Immunity
Descriptive Note : Annual rept 15 Aug 96-14 Aug 97
Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA
Personal Author(s) : Eck, Stephen ; Boxhorn, Heike
PDF Url : ADA335064
Report Date : SEP 1997
Pagination or Media Count : 28
Abstract : We sought to optimize the conditions under which B7-mediated gene transfer could effect antitumor immunity. Transduction of murine mammary carcinoma cell lines and human breast cancer cell lines with adenoviruses expressing B7-1 led to high levels of B7 expression. The expression - of mB7-1 on melanoma cells but not mammary carcinoma cells results in reduced growth rate. Interestingly, adenovims-mediated expression of mB7-1 on mammary carcinoma cells did not result in a reduced tumor growth rate.
Descriptors : *GENES, *IMMUNITY, *BREAST CANCER, NEOPLASMS, IN VITRO ANALYSIS, THERAPY, T LYMPHOCYTES, IN VIVO ANALYSIS, CELLS(BIOLOGY), ADENOVIRUSES, MAMMARY GLANDS, GROWTH(PHYSIOLOGY).
Subject Categories : Biochemistry
Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE