Accession Number : ADA335089

Title :   The Role of Integrins in Breast Cancer Metastasis

Descriptive Note : Annual rept 1 Sep 96-31 Aug 97

Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s) : Price, Janet

PDF Url : ADA335089

Report Date : SEP 1997

Pagination or Media Count : 19

Abstract : Our objective is to investigate the role of integrins in metastasis in human breast cancer. Integrins play an important role in cell adhesions and interactions with extracellular matrix proteins and the maintenance of normal differentiation. The scope of the study is to use variants of human breast cancer cell lines that differ in integrin expression to examine the relationship between integrin expression and metastasis to different organs. Variants of the human breast cancer cell line MDA-MB-435 with elevated expression expression of alpha v and alpha 6 integrins are highly metastatic to the lungs of nude mice. differences in expression of alternate

Descriptors :   *BREAST CANCER, EPITHELIUM, HUMANS, ADHESION, GLYCOPROTEINS, LUNG, MICE, CELLS(BIOLOGY), RIBONUCLEIC ACIDS, BONE MARROW, RECEPTOR SITES(PHYSIOLOGY), MAMMARY GLANDS, ALPHA PARTICLES, LYMPH NODES.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE