Accession Number : ADA335164

Title :   Support for HIV-1 Intervention Therapy

Descriptive Note : Final rept 30 Sep 92-29 Sep 97

Corporate Author : SRA TECHNOLOGIES INC FALLS CHURCH VA

Personal Author(s) : Weislow, Owen S.

PDF Url : ADA335164

Report Date : SEP 1997

Pagination or Media Count : 94

Abstract : Since 1992, SRA Technologies, Inc. has provided services in support of DoD interventional trials for HIV. Three working groups were established in the areas of molecular biology, cellular phenotyping and drug testing. Production level and repository services were provided for virus isolation, expansion, titration, sequencing, mutational analysis and drug susceptibility testing. Significant progress was made in the development of new as says for genotypic and phenotypic drug resistance, antibody neutralization, mutational analysis and for efficacy analysis of antiviral gene constructs. The contract contributed to discoveries in the area of drug resistance, and antibody neutralization of HIV and the development of diagnostic sequencing to support patient management in DoD clinics. The contractor was a major contributor in the discovery process leading to identification of HIV soluble and cell-associated inhibitory factors produced by CD3/CD28 antibody-stimulated cells in vitro.

Descriptors :   *THERAPY, *HUMAN IMMUNODEFICIENCY VIRUSES, CLINICAL MEDICINE, IN VITRO ANALYSIS, ANTIBODIES, MOLECULAR BIOLOGY, GENES, DRUGS, ANTIVIRAL AGENTS, VIRUSES, RESISTANCE(BIOLOGY).

Subject Categories : Biochemistry
      Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE