Accession Number : ADA335315

Title :   Tuning Biphenyl Dioxygenase for Extended Substrate Specificity and Enhanced Activity

Descriptive Note : Final rept 1 May 96-30 Sep 97

Corporate Author : CALIFORNIA UNIV RIVERSIDE COLL OF ENGINEERING

Personal Author(s) : Chen, Wilfred

PDF Url : ADA335315

Report Date : 30 SEP 1997

Pagination or Media Count : 5

Abstract : At the time when public concern about PCBs contamination in the environment is increasing, there is also an increasing interest in the development of novel biodegradation processes that can rapidly and effectively remove PCB's. However, some of the PCB congeners are known to be very resistant to aerobic biodegradation, particularly in the initial attack by the biphenyl dioxygenases. We seek to broaden the substrate specificity of biphenyl dioxygenase from Pseudomonas sp.

Descriptors :   *BIODEGRADATION, *AEROBIC PROCESSES, *POLYCHLORINATED BIPHENYLS, SUBSTRATES, DEOXYRIBONUCLEIC ACIDS, OXYGEN, AROMATIC HYDROCARBONS, CONTAMINATION, PSEUDOMONAS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Organic Chemistry
      Solid Wastes Pollution and Control

Distribution Statement : APPROVED FOR PUBLIC RELEASE