Accession Number : ADA335806

Title :   The Role of Basic Fibroblast Growth Factor in Human Breast Cancer

Descriptive Note : Annual rept 1 Sep 96-31 Aug 97

Corporate Author : UNIVERSITY OF MEDICINE AND DENTISTRY OFNEW JERSEY NEWARK

Personal Author(s) : Wieder, Robert

PDF Url : ADA335806

Report Date : SEP 1997

Pagination or Media Count : 20

Abstract : We have demonstrated that recombinant basic fibroblast growth factor (bFGF) inhibits proliferation and promotes programmed cell death in MCF-7 and a number of other breast cancer cells. These effects are opposite of the effects seen in fibroblasts. Since bFGF acts as a key angiogenesis factor in breast cancer and the bFGF content of breast cancer cells diminishes as they progress toward an ever more malignant phenotype, we investigated the effects of overexpressing bFGF in MCF-7 cells on the survival of these cells following treatment with two chemotherapeutic agents, etoposide and 5-fluorouracil. We contrasted these finding with data obtained in NIH 3T3 fibroblasts also transduced with bFGF.

Descriptors :   *FIBROBLASTS, *GROWTH(PHYSIOLOGY), *BREAST CANCER, HUMANS, CELLS(BIOLOGY), MAMMARY GLANDS, CHEMOTHERAPEUTIC AGENTS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE