Accession Number : ADA335816

Title :   Amphyphysin Autoimmunity in Breast Cancer and Stiff-Man Syndrome

Descriptive Note : Final rept 30 Sep 94-29 Sep 97

Corporate Author : YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE

Personal Author(s) : David, Carol

PDF Url : ADA335816

Report Date : OCT 1997

Pagination or Media Count : 15

Abstract : Stiff-man syndrome (SMS) is a rare neurological disease characterized by rigidity of the body musculature with superimposed painful spasms. Most patients with this disease exhibit autoimmunity to GABA-ergic neurons. It has been found in Prof. De Camilli's laboratory that, to date, all patients diagnosed with breast cancer and SMS, have autoantibodies against a novel synaptic-associated protein, amphiphysin. This research project is to further define the role of anti-amphiphysin antibodies in the development and/or detection of breast cancer and to further understand the function of this protein and how the autoimmunity may arise.

Descriptors :   *AUTOIMMUNIZATION, *BREAST CANCER, DETECTION, PROTEINS, ANTIBODIES, MUSCLES, NEUROLOGY, CONTRACTION.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE