Accession Number : ADA335852

Title :   Does Subsequent Pregnancy Influence Breast Cancer Survival.

Descriptive Note : Annual rept. 15 Sep 96-14 Sep 97,

Corporate Author : SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Personal Author(s) : Senie, Ruby T.

PDF Url : ADA335852

Report Date : OCT 1997

Pagination or Media Count : 23

Abstract : This retrospective study is designed to provide an assessment of the risk of recurrence and death associated with pregnancy following primary and adjuvant breast cancer treatment. This major concern of young breast cancer patients who may have delayed childbearing. A collaborative record-linkage study is underway using the unique computerized records maintained by the Kaiser Permanente of Northern California. Through linkage of the cancer registry and hospitalization records, young breast cancer patients with a history of subsequent pregnancy have been identified. Medical record review is currently being conducted to collect data on epidemiologic risk factors and breast cancer stage, treatment and outcome factors. Four breast cancer cases without a history of pregnancy after breast cancer will be matched to each case by year and age at diagnosis, stage of disease, months of survival from diagnosis to first pregnancy outcome, and disease status during early pregnancy. Matched analyses methods will be used to compare disease free survival among cases with and without a history of subsequent pregnancy. Known and suspected prognostic factors will be controlled in the analysis. Among cases with a history of subsequent pregnancy, the effect of reproductive events prior to diagnosis, the months between diagnosis and first pregnancy, the number of subsequent pregnancies, and birth outcomes will be studied.

Descriptors :   *STATISTICAL DATA, *SURVIVAL(GENERAL), *DIAGNOSIS(MEDICINE), *MEDICAL RESEARCH, *PREGNANCY, *WOMEN, *BREAST CANCER, RISK, HISTORY, RECORDS MANAGEMENT, PATIENTS, HOSPITALIZATIONS, DEATH, EPIDEMIOLOGY, REPRODUCTION(PHYSIOLOGY).

Subject Categories : Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE