Accession Number : ADA335941

Title :   Tumor-Specific Immunotherapy of Mammary Cancer

Descriptive Note : Annual rept 17 Aug 96-16 Aug 97

Corporate Author : MARYLAND UNIV BALTIMORE

Personal Author(s) : Ostrand-Rosenberg, Suzanne

PDF Url : ADA335941

Report Date : SEP 1997

Pagination or Media Count : 17

Abstract : For many patients with mammary cancer the primary tumor can be successfully treated by surgical removal, however the long-term prognosis is not favorable because of the high frequency of metastatic disease which is not treatable by current approaches. Our goal is to develop vaccination strategies to minimize metastatic disease. We postulate that an improvement in the generation of mammary carcinoma-specific CD4(+) T helper lymphocytes will facilitate development of CD8-mediated tumor immunity.

Descriptors :   *IMMUNIZATION, *BREAST CANCER, MOLECULES, PEPTIDES, NEOPLASMS, GENES, T LYMPHOCYTES, IMMUNITY, CELLS(BIOLOGY), ANTIGENS, VACCINES, MAMMARY GLANDS, HISTOCOMPATIBILITY, METASTASIS.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE