Accession Number : ADA335989

Title :   The Interaction of Steroid Hormones and Oncogene in Breast Cancer

Descriptive Note : Annual rept 15 Sep 96-14 Sep 97

Corporate Author : BAYLOR COLL OF MEDICINE HOUSTON TX

Personal Author(s) : Tsai, Sophia Y.

PDF Url : ADA335989

Report Date : OCT 1997

Pagination or Media Count : 40

Abstract : We propose to generate a novel inducible bitransgenic system to examine the effect of the expression of a target oncogene, the polyoma middle T antigen, on the onset of mammary epithelium hyperplasia. Using this inducible system, the specific expression of a transgene can be initiated by the administration of an external compound. To establish such a regulatable system, we have introduced the regulator and the inducible target separately into mouse embryos to generate transgenic mouse lines. To target the expression of the regulator in mammary glands, we have placed the regulator under the control of the MMTV-LTR. Transgenic lines of the regulator and the target, polyoma middle T antigen have been generated. These lines are currently being crossed to generate bitransgenic lines and the expression of the target oncogene will be induced by administration of progesterone antagonists.

Descriptors :   *HORMONES, *STEROIDS, *BREAST CANCER, EPITHELIUM, MICE, EMBRYOS, ANTIGENS, PHARMACOLOGICAL ANTAGONISTS, MAMMARY GLANDS, PROGESTERONE, ESTROGENS, ONCOGENIC VIRUSES.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE