Accession Number : ADA335991

Title :   The Role of Cyclin D1 Overexpression in Breast Cancer Progression

Descriptive Note : Annual rept 15 Jul 96-14 Jul 97

Corporate Author : COLUMBIA UNIV NEW YORK

Personal Author(s) : Weinstein, I. B.

PDF Url : ADA335991

Report Date : AUG 1997

Pagination or Media Count : 24

Abstract : Our previous studies concentrated on the role of cyclin D1 in breast cancer. In recent studies we have found that cyclin E, which also plays a critical role in the G1 to S progression of the cell cycle, is also frequently overexpressed in breast cancer cell lines. We found that ectopic overexpression of cyclin E stimulates the growth of fibroblast cell lines but inhibits the growth of some mammary epithelial cell lines.

Descriptors :   *BREAST CANCER, EPITHELIUM, PROTEINS, NEOPLASMS, CYCLES, THERAPY, FIBROBLASTS, CELLS(BIOLOGY), LOOPS, MAMMARY GLANDS, HOMEOSTASIS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE