Accession Number : ADA336351

Title :   Estimation of Human Toxicity From Animal Inhalation Toxicity Data: 1. Minute Volume-Body Weight Relationships Between Animals And Man.

Corporate Author : DEFENCE RESEARCH ESTABLISHMENT SUFFIELDRALSTON (ALBERTA)

Personal Author(s) : Bide, R. W. ; Armour, S. J. ; Yee, E.

PDF Url : ADA336351

Report Date : OCT 1997

Pagination or Media Count : 50

Abstract : The relationship between body weight (BW) and respiratory minute volume (Vm) was reviewed by collecting a data base from the literature of minute volume rates that encompassed species from mice at 12 g body weight to horses and a giraffe at 500 kg body weight. The data were separated into anesthetized and non-anesthetized groups and juvenile animals were removed from the non-anesthetized group. The final data set of non-anesthetized animals contained 131 studies representing 2125 animals and 18 species. The data show a power-law (allometric) relationship between the minute volume and body weight. The scaling or allometric parameters in this power-law have been estimated using a linear regression of the logarithms of the minute volume against body weight. The resulting allometric equations were; Log10Vm = -0.286+ 0.802 Log10BW or Vm = 0.518 BW0.802. From these equations a corresponding set of minute volumes were obtained for various body weights of humans eg. 15.6 L/min for a 70 kg human. The results of the analyses were compared to similar studies in the literature. The relationship is recommended for military uses because it is derived from non-anesthetized, young adult mammals which are expected to mimic the soldier.

Descriptors :   *TOXICITY, *HUMAN BODY, *BODY WEIGHT, *LABORATORY ANIMALS, DATA BASES, MAMMALS, ARMY PERSONNEL, ESTIMATES, PHYSIOLOGICAL EFFECTS, RESPIRATORY SYSTEM, MICE, LINEAR REGRESSION ANALYSIS, ANESTHESIA, BREATHING APPARATUS, INHALATION, HORSES.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE