Accession Number : ADA336400

Title :   Biochemistry and Chemotherapy of Malaria and Leishmaniasis.

Descriptive Note : Final rept. 2 Nov 92-31 Oct 97

Corporate Author : MASSACHUSETTS UNIV AMHERST

Personal Author(s) : Nolan, Linda

PDF Url : ADA336400

Report Date : DEC 1997

Pagination or Media Count : 34

Abstract : Malaria is the world's most ravaging infectious disease. It is rampant throughout much of the tropics and some of the temperate areas of the world. It threatens a third of the world's population, presently afflicting hundreds of millions of people, causing several million deaths annually and possibly generating as many as 92 million new clinical cases each year. The socioeconomic drain of the disease is enormous. Resurgence of this pestilence during the past 20 years due to global warming, drug resistance, and other factors has prompted increased research efforts in the production of an effective vaccine. In the interim, there must be a reliance on chemotherapy for prevention and treatment of the disease. The current research addressed the need to develop a broad-spectrum antimalarial. Research efforts focused on the propagation of malarial Parasites in vitro for the purpose of studying the unique biochemistry of the parasite with the goal of chemotherapeutic exploitation.

Descriptors :   *BIOCHEMISTRY, *MALARIA, *LEISHMANIASIS, *CHEMOTHERAPY, GLOBAL, PRODUCTION, ECONOMICS, ENZYMES, CLINICAL MEDICINE, POPULATION, DEOXYRIBONUCLEIC ACIDS, IN VITRO ANALYSIS, SPECTRA, DRAINAGE, HEATING, BROADBAND, TROPICAL REGIONS, PARASITES, INFECTIOUS DISEASES, DRUGS, SOCIOLOGY, ANTIMALARIALS, VACCINES, RESISTANCE(BIOLOGY), TEMPERATE REGIONS.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE