Accession Number : ADA336527
Title : Mechanisms of Breast Cancer-Induced Osteolysis.
Descriptive Note : Annual rept. 15 Jul 96-14 Jul 97,
Corporate Author : BARNES-JEWISH HOSPITAL ST LOUIS MO
Personal Author(s) : Teitelbaum, Steven L.
PDF Url : ADA336527
Report Date : AUG 1997
Pagination or Media Count : 20
Abstract : We have demonstrated expression level of the integrin alphavbeta3 correlates with organ-specific targeting of human breast tumor cells, such that low integrin expressing cells preferentially home to bone, while high alphavbeta3 expressing cells preferentially target to lungs. In addition, we have shown that the MDA-231 cells express the osteoclastogenic cytokine IL-6, and directly or indirectly promote expression of a second osteoclast promoting cytokine, IL-1 by the host. Expression of these cytokines likely contributes to the tumor induced osteolysis.
Descriptors : *MEDICAL RESEARCH, *BONE MARROW, *BREAST CANCER, *OSTEOLYSIS, HUMANS, NEOPLASMS, LUNG, HYPOTHESES, CELLS(BIOLOGY), MAMMARY GLANDS, TISSUE EXTRACTS.
Subject Categories : Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE