Accession Number : ADA336527

Title :   Mechanisms of Breast Cancer-Induced Osteolysis.

Descriptive Note : Annual rept. 15 Jul 96-14 Jul 97,

Corporate Author : BARNES-JEWISH HOSPITAL ST LOUIS MO

Personal Author(s) : Teitelbaum, Steven L.

PDF Url : ADA336527

Report Date : AUG 1997

Pagination or Media Count : 20

Abstract : We have demonstrated expression level of the integrin alphavbeta3 correlates with organ-specific targeting of human breast tumor cells, such that low integrin expressing cells preferentially home to bone, while high alphavbeta3 expressing cells preferentially target to lungs. In addition, we have shown that the MDA-231 cells express the osteoclastogenic cytokine IL-6, and directly or indirectly promote expression of a second osteoclast promoting cytokine, IL-1 by the host. Expression of these cytokines likely contributes to the tumor induced osteolysis.

Descriptors :   *MEDICAL RESEARCH, *BONE MARROW, *BREAST CANCER, *OSTEOLYSIS, HUMANS, NEOPLASMS, LUNG, HYPOTHESES, CELLS(BIOLOGY), MAMMARY GLANDS, TISSUE EXTRACTS.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE