Accession Number : ADA336699

Title :   The Role of KIP2 in Breast Cancer.

Descriptive Note : Annual rept. 1 Sep 96-31 Aug 97

Corporate Author : BAYLOR UNIV HOUSTON TX

Personal Author(s) : Elledge, Stephen J.

PDF Url : ADA336699

Report Date : SEP 1997

Pagination or Media Count : 34

Abstract : The cell cycle is regulated by the action of a family of cyclin dependent kinases (Cdks) which catalyze particular cell cycle transitions. Cdks are positively regulated through interaction with cyclins and are negatively regulated through phosphorylation and through association with inhibitory proteins of the CIP/KIP and INK4 families. Our research has focused on the role of p57KIP2 in development and cancer. We have found that p57KIP2 is expressed in a highly cell type specific manner during embryonic development and in adult tissues, being most highly expressed in terminally differentiated cells. Through analysis of p57KIP2 deficient mice, however, we have found that p57KIP2 is required for normal development of several tissues including the kidney, lens, muscle, and bone. We also discovered the p57 is involved in the human overgrowth and cancer predisposition disease Beckwith-Wiedemann Syndrome, BWS. Current studies are aimed at understanding in greater detail the function of p57KIP2 and its possible role in human cancers.

Descriptors :   *BREAST CANCER, TISSUES(BIOLOGY), HUMANS, PROTEINS, CLINICAL MEDICINE, MUTATIONS, TRANSITIONS, MICE, CARCINOGENS, MEDICAL SERVICES, INHIBITION, EMBRYOS, PREGNANCY, CELLS(BIOLOGY), ADULTS, MAMMARY GLANDS, GROWTH(PHYSIOLOGY), PHOSPHORYLATION, PHOSPHORUS TRANSFERASES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE