Accession Number : ADA336848

Title :   The Physiology of Acute Mountain Sickness in Women

Descriptive Note : Annual rept 1 Oct 96-30 Sep 97

Corporate Author : LOVELACE INSTITUTES ALBUQUERQUE NM

Personal Author(s) : Loeppky, Jack

PDF Url : ADA336848

Report Date : OCT 1997

Pagination or Media Count : 34

Abstract : The purpose of these investigations is to determine whether symptoms of acute mountain sickness (AMS) are affected by mensural cycle phase and oral contraceptives in women and whether the severity of AMS differs from men. The experimental test procedures have been selected, tested and performed on 10 subjects. The experiments consist of 12 hours exposures to a simulated altitude of 16,000 ft. Measurements of global and regional (brain magnetic resonance imaging) fluid homeostasis, ventilation, cognitive and autonomic function are emphasized in relation to control measurements and AMS symptoms. Women are tested in luteal and follicular phases of the menstrual cycle, confirmed by progesterone levels, and while on contraceptives and compared with men. Early results (n=10) suggest that a constant urine volume and transcapillary albumin escape rate and a declining plasma volume at altitude are associated with a high tolerance to AMS.

Descriptors :   *PHYSIOLOGY, *WOMEN, *ALTITUDE SICKNESS, COGNITION, SIGNS AND SYMPTOMS, CYCLES, MOUNTAINS, ADVERSE CONDITIONS, FLUIDS, ALTITUDE, URINE, ORAL INTAKE, HOMEOSTASIS, MENSTRUATION, PROGESTERONE, ADAPTATION(PHYSIOLOGY), CONTRACEPTION.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE