Accession Number : ADA337014

Title :   Breast Cancer Incidence in Occupational Cohorts Exposed to Ethylene Oxide and polychiorinated Biphenyls.

Descriptive Note : Annual rept. 1 Aug 96-31 Jul 97.

Corporate Author : NATIONAL INST FOR OCCUPATIONAL SAFETY AND HEALTH CINCINNATI OH

Personal Author(s) : Ward, Elizabeth M.

PDF Url : ADA337014

Report Date : SEP 1997

Pagination or Media Count : 12

Abstract : NIOSH is evaluating breast cancer incidence in two large, previously assembled cohorts of workers. One of the cohorts includes approximately 10,000 women with exposure to ethylene oxide (ETO), a direct alkylating agent which produces mammary tumors in mice. The other cohort includes over 13,000 women exposed to polychlorinated biphenyls (PCBs), a group of chemicals suspected to be carcinogenic to the breast because of their lipophilic and estrogenic activities. Each cohort represents the largest and best defined female study cohort in the U.S. for the respective exposure. The primary activities for this year have focused on: (a) identifying mailing addresses for individuals in the two study cohorts, (b) identification of next-of-kin for deceased individuals, (c) acquisition of medical records for cancer deaths, and (d) obtaining approval to provide an Assurance of Confidentiality for the study as allowed by section 308(d) of the Public Health Service Act. Address identification is virtually complete for living members of the cohort and the first phase of data collection will start in October of 1997.

Descriptors :   *CARCINOGENS, *MAMMARY GLANDS, *POLYCHLORINATED BIPHENYLS, *ETHYLENE OXIDE, *BREAST CANCER, ACQUISITION, EXPOSURE(GENERAL), CHEMICALS, NEOPLASMS, IDENTIFICATION, MEDICINE, DATA ACQUISITION, ALKYLATION, RECORDS, MICE, FEMALES, CANCER.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE