Accession Number : ADA337448

Title :   A Miniswine Model of Heatstroke.

Corporate Author : ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s) : Gaffin, Stephen L. ; Gentile, Brian ; Koratich, Michael ; Leva, Natalie ; Hubbard, Roger

PDF Url : ADA337448

Report Date : 1997

Pagination or Media Count : 31

Abstract : We developed a miniswine model of passive heatstroke, in part, to explain the variable hyper-, normo- and hypokalemia seen in heatstroke victims. After a baseline period (Tamb=26-270C), anesthetized and instrumented miniswine (n=13, mass=44.6 kg) were ramped t9 41-430C, 60% RH; 13 controls were treated identically, but Tre was maintained at 3800. Tre of the experimental miniswine rose nearly linearly to 454600 until death (approx. 4h). The response patterns of mean arterial pressure, heart rate, plasma K+, LPS, Ca++, inorganic phosphate, lactate and a variety of other clinical chemical and physiological variables were determined. An explanation for the variability of plasma k+ in heatstroke victims was proposed. This model may be useful in characterizing the multisystemic pathology of severe heat injury and be useful for assessing innovative therapeutic regimens.

Descriptors :   *CLINICAL MEDICINE, *PHYSIOLOGICAL EFFECTS, *RESPONSE(BIOLOGY), *HEAT STROKE, CHEMICALS, PASSIVE SYSTEMS, VARIABLES, PATTERNS, INSTRUMENTATION, CASUALTIES, THERAPY, WOUNDS AND INJURIES, PATHOLOGY, DEATH, HEART RATE, ANESTHESIA, INORGANIC COMPOUNDS, PHOSPHATES, BLOOD PRESSURE, SWINE, LACTATES.

Subject Categories : Medicine and Medical Research
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE