Accession Number : ADA337481
Title : The Role of Oxidative Stress in Apoptosis of Breast Cancer Cells
Descriptive Note : Annual rept 29 Aug 96-28 Aug 97
Corporate Author : ARIZONA UNIV TUCSON
Personal Author(s) : Briehl, Margaret M.
PDF Url : ADA337481
Report Date : SEP 1997
Pagination or Media Count : 20
Abstract : In response to specific stimuli, normal cells undergo a process of cell suicide called apoptosis. This project is testing the hypothesis that oxidative stress plays a critical role in the mechanism of apoptosis induced by treatment of human breast cancer cells with tumor necrosis factor-alpha (TNF). TNF treatment of MCF-7 cells was found to increase the expression and activity of manganese superoxide dismutase.
Descriptors : *OXIDATION, *CELLS(BIOLOGY), *BREAST CANCER, HUMANS, STRESS(PHYSIOLOGY), NEOPLASMS, STIMULI, RESPONSE(BIOLOGY), ANTIOXIDANTS, NECROSIS, MAMMARY GLANDS, MANGANESE, ENZYME PRECURSORS, SUPEROXIDE DISMUTASE, OXIDOREDUCTASES.
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE