Accession Number : ADA337481

Title :   The Role of Oxidative Stress in Apoptosis of Breast Cancer Cells

Descriptive Note : Annual rept 29 Aug 96-28 Aug 97

Corporate Author : ARIZONA UNIV TUCSON

Personal Author(s) : Briehl, Margaret M.

PDF Url : ADA337481

Report Date : SEP 1997

Pagination or Media Count : 20

Abstract : In response to specific stimuli, normal cells undergo a process of cell suicide called apoptosis. This project is testing the hypothesis that oxidative stress plays a critical role in the mechanism of apoptosis induced by treatment of human breast cancer cells with tumor necrosis factor-alpha (TNF). TNF treatment of MCF-7 cells was found to increase the expression and activity of manganese superoxide dismutase.

Descriptors :   *OXIDATION, *CELLS(BIOLOGY), *BREAST CANCER, HUMANS, STRESS(PHYSIOLOGY), NEOPLASMS, STIMULI, RESPONSE(BIOLOGY), ANTIOXIDANTS, NECROSIS, MAMMARY GLANDS, MANGANESE, ENZYME PRECURSORS, SUPEROXIDE DISMUTASE, OXIDOREDUCTASES.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE