Accession Number : ADA337489

Title :   The Molecular Epidemiology of Breast Cancer: Risk From Environmental Exposures and Genetic Susceptibility

Descriptive Note : Annual rept 1 Sep 96-31 Aug 97

Corporate Author : STATE UNIV OF NEW YORK AT BUFFALO AMHERST

Personal Author(s) : Moysich, Kirsten ; Freudenheim, Jo L.

PDF Url : ADA337489

Report Date : SEP 1997

Pagination or Media Count : 48

Abstract : This report includes results from a case-control study examining the relation of serum levels of DDE, hexachlorbenzene (HCB), and poly chlorinated biphenyls (PCBs) to risk of postmenopausal breast cancer. The study sample included 154 primary, incident, histologically confirmed, breast cancer cases and 192 community controls. In the entire sample there was no evidence of an adverse effect associated with serum levels of DDE, HCB, and several PCB exposure measures: total PCBs, total number of detected PCB congener peaks, and PCB congener groups. We consistently observed effect modification by history of lactation with respect to all exposures.

Descriptors :   *EPIDEMIOLOGY, *BREAST CANCER, RISK, MOLECULES, POLYMERS, ORGANIC COMPOUNDS, EXPOSURE(PHYSIOLOGY), BLOOD SERUM, CHLORINATION, WOMEN, GENETICS, HISTOLOGY, LACTATES, BIPHENYL.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE