Accession Number : ADA337492

Title :   Regulation of Epidermal Growth Factor Receptor Expression by PML in Human Breast Cancer

Descriptive Note : Annual rept 1 Aug 96-31 Jul 97

Corporate Author : CANCER INST OF NEW JERSEY PISCATAWAY

Personal Author(s) : Chin, Khew-Voon

PDF Url : ADA337492

Report Date : OCT 1997

Pagination or Media Count : 14

Abstract : We have determined that PML is a novel growth suppressor that was found to be from chromosome 15 and fused with the retinoic acid receptor-a gene on chromosome 17 (t(15; 17) in acute promyelogenous leukemia (APL). PML is a member of the newly identified growing family of RING finger domain proteins that includes the breast cancer susceptibility gene BRCA1, ret, and T18, whose functions ranged from transactivation of viral genes to DNA repair and extinction of homeotic genes. Expression of PML has been shown to be altered in breast cancer.

Descriptors :   *EPIDERMIS, *GROWTH(PHYSIOLOGY), *BREAST CANCER, EPITHELIUM, HUMANS, PROTEINS, DEOXYRIBONUCLEIC ACIDS, CHROMOSOMES, GENES, VIRUSES, CELLS(BIOLOGY), LESIONS, MAMMARY GLANDS, SUPPRESSORS, LEUKEMIA.

Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE