Accession Number : ADA337541

Title :   PET-FDG Imaging in Metastatic Breast Cancer Treated with High Dose Chemotherapy and Stem Cell Support

Descriptive Note : Annual rept 1 Sep 96-31 Aug 97

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s) : Alavi, Abass

PDF Url : ADA337541

Report Date : SEP 1997

Pagination or Media Count : 21

Abstract : This study is designed to assess the effectiveness of positron emission tomography (PET) with fluoro deoxyglucose in patients with metastatic breast cancer undergoing high dose chemotherapy with stem cell rescue. It includes patients enrolled on two high dose chemotherapy trials (PBT-1 and UCPP #3195). So far, 31 patients have been enrolled in the protocol, and the study is proceeding as planned. We have performed a preliminary analysis of the PET studies of 24 patients performed before high dose chemotherapy. In this subgroup of patients, 17 had active disease demonstrated on the PET study, and 7 had no evidence of metabolically active disease. Two subjects had disease involvement demonstrated only on PET imaging and proven at pathology or follow-up. Several repeat studies have been performed and will be analyzed when enough prognostic information becomes available. Patient accrual is ongoing and the study is proceeding as scheduled. PET FDG imaging is a promising tool that can potentially predict early therapeutic failure.

Descriptors :   *TOMOGRAPHY, *CHEMOTHERAPY, *BREAST CANCER, IMAGE PROCESSING, EMISSION, MEMBRANES(BIOLOGY), FAILURE, DOSAGE, PATHOLOGY, CELLS(BIOLOGY), TRANSPLANTATION, BONE MARROW, GLUCOSE, POSITRONS, METASTASIS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE