Accession Number : ADA337552

Title :   Role of CD44 and Variants in Membrane-Cytoskeleton Interactions, Adhesion, Metastasis and Human Breast Cancers

Descriptive Note : Annual rept 1 Aug 96-31 Jul 97

Corporate Author : MIAMI UNIV FL

Personal Author(s) : Bourguignon, Lilly

PDF Url : ADA337552

Report Date : OCT 1997

Pagination or Media Count : 45

Abstract : Previously, we have reported that the expression of CD44v3,8-10 is closely correlated with the metastatic behavior of human breast carcinomas. In this study we have chosen a new breast cancer metastasis model system, Met-I cells (derived from a high metastatic potential tumor in transgenic mice expressing polyomavirus middle T oncogene), to further analyze the functional property of this CD44 variant isoform. We used a variety of techniques (e.g. RT-PCR, Southern blot, immunoprecipitation and immuno-blot techniques).

Descriptors :   *MEMBRANES(BIOLOGY), *ADHESION, *METASTASIS, *BREAST CANCER, HUMANS, BIOCHEMISTRY, GLYCOPROTEINS, NEOPLASMS, CHEMICAL PRECIPITATION, CELLS(BIOLOGY), IMMUNOASSAY, MAMMARY GLANDS.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE