Accession Number : ADA337557

Title :   Vaccines to Breast Cancer Based on p53 Mutants

Descriptive Note : Annual rept 1 Sep 96-31 Aug 97

Corporate Author : WISTAR INST OF ANATOMY AND BIOLOGY PHILADELPHIA PA

Personal Author(s) : Ertl, Hildegund C.

PDF Url : ADA337557

Report Date : SEP 1997

Pagination or Media Count : 37

Abstract : The aim of this proposal is to test vaccines expressing mouse mutant or wild-type p53 for induction of protective immunity against challenge with tumor cell lines expressing either mutant or high levels of wild-type p53. The long term goal is to develop an efficacious vaccine with broad applicability for the treatment of human breast cancer patients. Our studies to date show that vaccinia virus recombinants expressing full-length wild-type p53 provide up to 70% protection to one of the model tumor cell lines under investigation. Vaccine efficacy can be improved by using mouse IL-l2 as an adjuvant.

Descriptors :   *BREAST CANCER, HUMANS, PROTEINS, NEOPLASMS, DEOXYRIBONUCLEIC ACIDS, MUTATIONS, GENES, MICE, IMMUNITY, CELLS(BIOLOGY), VACCINES, PREVENTIVE MEDICINE, RESISTANCE(BIOLOGY).

Subject Categories : Medicine and Medical Research
      Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE