Accession Number : ADA337587

Title :   Development of Ultra Long Duration Local Anesthetic Agents in a Rat Model.

Descriptive Note : Final rept. 15 Dec 92-31 Dec 95,

Corporate Author : WALTER REED ARMY MEDICAL CENTER WASHINGTON DC

Personal Author(s) : Kline, Mark D.

PDF Url : ADA337587

Report Date : NOV 1997

Pagination or Media Count : 72

Abstract : For decades anesthesiologists have sought an agent that would provide local anesthesia lasting for days rather than hours. The ideal ultra-long duration local anesthetic agent would affect sensory but not motor fibers, be free of local irritant effects, have a high therapeutic index, and provide analgesia for several days. No agent currently exists that meets all these criteria. Lecfthin coated microcrystal technology shows promise in improving the delivery of local anesthetics and analgesics. In this study three different agents were developed and tested in animal models to establish possible clinical efficacy.

Descriptors :   *RATS, *CLINICAL MEDICINE, *DIAGNOSIS(MEDICINE), *ANESTHESIOLOGISTS, MILITARY PERSONNEL, DELIVERY, MILITARY RESEARCH, CIVILIAN POPULATION, ANESTHESIA, LABORATORY ANIMALS, ANALGESICS, LOCAL ANESTHETICS.

Subject Categories : Personnel Management and Labor Relations
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE