Accession Number : ADA337820
Title : Breast Cancer in Ataxia Telangiectasia Carriers.
Descriptive Note : Final rept. 15 Aug 94-14 Aug 97,
Corporate Author : TEXAS UNIV AT HOUSTON
Personal Author(s) : Weil, Michael M.
PDF Url : ADA337820
Report Date : SEP 1997
Pagination or Media Count : 13
Abstract : Individuals that carry a single mutated copy of the ATM gene appear clinically normal but may be at increased risk for breast cancer and for normal tissue damage from radiotherapy. We have developed a direct sequencing assay that can identify mutations and polymorphisms in the translated region of the ATM message. This assay is being used in a pilot study of the incidence of ATM mutations and polymorphisms in cancer patients, particularly breast cancer patients. If successful, this pilot study will be expanded to a full scale epidemiological study of the role of ATM mutations and polymorphisms in breast cancer susceptibility and normal tissue damage from radiotherapy.
Descriptors : *GENES, *RADIOTHERAPY, *BREAST CANCER, TISSUES(BIOLOGY), RISK, DAMAGE, MUTATIONS, PATIENTS, PILOT STUDIES, EPIDEMIOLOGY, POLYMORPHISM, ATAXIA.
Subject Categories : Genetic Engineering and Molecular Biology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE