Accession Number : ADA337820

Title :   Breast Cancer in Ataxia Telangiectasia Carriers.

Descriptive Note : Final rept. 15 Aug 94-14 Aug 97,

Corporate Author : TEXAS UNIV AT HOUSTON

Personal Author(s) : Weil, Michael M.

PDF Url : ADA337820

Report Date : SEP 1997

Pagination or Media Count : 13

Abstract : Individuals that carry a single mutated copy of the ATM gene appear clinically normal but may be at increased risk for breast cancer and for normal tissue damage from radiotherapy. We have developed a direct sequencing assay that can identify mutations and polymorphisms in the translated region of the ATM message. This assay is being used in a pilot study of the incidence of ATM mutations and polymorphisms in cancer patients, particularly breast cancer patients. If successful, this pilot study will be expanded to a full scale epidemiological study of the role of ATM mutations and polymorphisms in breast cancer susceptibility and normal tissue damage from radiotherapy.

Descriptors :   *GENES, *RADIOTHERAPY, *BREAST CANCER, TISSUES(BIOLOGY), RISK, DAMAGE, MUTATIONS, PATIENTS, PILOT STUDIES, EPIDEMIOLOGY, POLYMORPHISM, ATAXIA.

Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE