Accession Number : ADA337868
Title : A Study of Ultrasonic Wavefront Distortion Compensation
Descriptive Note : Annual rept. 1 Sep 96-31 Aug 97,
Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA
Personal Author(s) : Zhu, Qing
PDF Url : ADA337868
Report Date : SEP 1997
Pagination or Media Count : 94
Abstract : High resolution and high contrast ultrasound imaging for early detection of breast lesions is limited by acoustic wavefront distortion which is developed as coherent waves propagate inside the breast tissue. Wavefront distortion causes image degradation. We have developed a novel signal processing technique, called Toward Inverse Filtering (TIF), to compensate such distortion. In vitro one-way distortion compensation has shown that contrast resolution has been improved significantly with TIF. We have applied TIF to two-way pulse-echo imaging data obtained from phantom. Preliminary results have shown that TIF offers more improvement of contrast of low echogenic lesions than existing compensation techniques. In addition to signal processing work, we have fabricated a prototype two-dimensional (2-D) ultrasound array operating at 1 MHz. Two-dimensional array will allow us to implement TIF in 2-D for further contrast improvement and will be used as a tool for clinical studies. In addition to wavefront compensation and array construction work, we have developed a novel method which combines ultrasound and near infrared diffused light to improve lesion detection sensitivity and specificity. This work was not proposed in the original proposal but it is an important discovery along the track of the PI's breast cancer research.
Descriptors : *DETECTION, *HIGH RESOLUTION, *ULTRASONICS, *BREAST CANCER, SIGNAL PROCESSING, DEGRADATION, TWO DIMENSIONAL, CLINICAL MEDICINE, IMAGES, MEDICAL RESEARCH, WAVEFRONTS, MAMMARY GLANDS.
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE